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In other studies, isoptin sr did not generally induce significant negative inotropic, chronotropic, or dromotropic effects in patients with preserved left ventricular function receiving low or moderate doses of propranolol less than or equal to 320 mg day ; in some patients, however, combined therapy did produce such effects.

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Propranolol is highly lipophilic and is almost completely absorbed after oral administration.

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Propranolol doses of 160 mg day in 39 volunteers 27m, 12f had no effect on the exposure to topiramate at a dose of 200 mg day of topiramate.

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